Forum Diagnosticum No.01/2012
Obesity and Metabolic Syndrome
In recent decades there has been an increased occurrence of obesity worldwide. Obesity and metabolic disorders have become a serious threat to human health on this planet now and in the upcoming days. Obesity and metabolic syndrome are related to dyslipidemia, impaired glucose metabolism, hypertension and represent a number of risk factors including coronary heart disease, atherosclerosis and diabetes in which inflammation plays an important role in its pathogenesis. Moreover, the increase of obesity cases decreases life expectancy rate. (4, 5, 9, 40, 42)
Currently, it is clear that adipose tissue is not simply a storage and thermoregulatory organ, but also an active organ that secretes various mediators known as adipokines. Adipose tissue does not only affect the overall metabolism, but also the functionality of various organs and tissues such as muscles, the liver, brain and blood vessels. Increased fat cell mass triggers the imbalance release of hormones which eventually causes a variety of serious health problems. Moreover, the obesity complication, or commonly known as metabolic syndrome, is characterized by insulin resistance which is often followed by the destruction of pancreatic beta cells, impaired glucose tolerance and type 2 diabetes, dyslipidemia, hypertension and premature heart disease. (4, 9, 41)
Obesity and metabolic syndrome have been proven to cause a variety of disorders, including the function of the heart and blood vessels, kidney, liver and others. Laboratory test is one of the important parameters, both in the diagnosis and treatment of obesity and metabolic syndrome, for estimating the severity of the disease, following up disease progression and assessing the effectiveness of the therapy. In addition, laboratory test also allows the clinician to get useful information so that the appropriate treatment decisions can be taken.
Author: Serlayan Herman (Prodia Clinical Laboratory)